Careseng contains the concentrated extract of several anti-cancer compounds found in ginseng, an herb with a long history of use in traditional Chinese medicine. Cancer Care patients undergoing cell culture studies on breast cancer, liver cancer, colon cancer, prostate cancer, lung cancer, pancreatic cancer, and brain cancer cells have shown that ginseng extract induces the death of cancer cells (technically known as apoptosis) by impeding the growth of new blood vessels feeding the cancerous tumors.
Careseng contains the concentrated extract of several anti-cancer compounds found in ginseng, an herb with a long history of use in traditional Chinese medicine. Cancer Care patients undergoing cell culture studies on breast cancer, liver cancer, colon cancer, prostate cancer, lung cancer, pancreatic cancer, and brain cancer cells have shown that ginseng extract induces the death of cancer cells (technically known as apoptosis) by impeding the growth of new blood vessels feeding the cancerous tumors.
In low concentrations, Careseng was shown to stop cancer cells from growing, and in higher concentrations it caused cell death. Furthermore, when combined with chemotherapy the effectiveness of chemotherapy drugs were enhanced.
Careseng Alternative Treatment for Cancer
Two preliminary studies on Careseng also show significant inhibition of cancer growth. What is more promising is that no adverse side effects have been reported due to the use of Careseng.
The two main active anti-cancer agents in Careseng are Rh2 and a variety of plant compounds known as dammarane sapogenins found especially in the araliaceae (a large family of mostly tropical shrubs and trees, of which ginseng is one). Cell culture studies of dammarane sapogenins demonstrate that in addition to inducing cell apoptosis, it also inhibits cancer cell proliferation, induces differentiation of cancer cells into benign cells, and blocks the function of a protein (P-glycoprotein) found in cancer cells, which is responsible for multi-drug resistance. Thus the efficacy of chemotherapy drugs is enhanced. There are also other possible anti-cancer effects.
References for Careseng
Shen, J., Zhang, Y., Shen, H., Pan, H., Xu, L., Yuan, L., & Ding, Z. (2018). The synergistic effect of 2,3,5,4′-Tetrahydroxystilbene-2-O-β-d-glucoside combined with Adriamycin on MCF-7 breast cancer cells. Drug design, development, and therapy, 12, 4083–4094. https://doi.org/10.2147/DDDT.S186028
Careseng for chemotherapyinduced myelosuppressionJia, W. and Yan, H. and Bu, X. and Liu, G. and Zhao, Y., Aglycone Protopanaxadiol, a ginseng saponin inhibits P-glycoprotein and sensitizes chemotherapy drugs on multidrug-resistant cancer cells, Journal of Clinical Oncology, 22,14\_,pages 9663-9663, doi = 10.1200/jco.2004.22.90140.9663, PMID: 28016290, https://doi.org/10.1200/jco.2004.22.90140.9663 Aglycone Protopanaxadiol (aPPD) is an aglycone derivative of ginseng saponins. Our previous work showed that a natural ginseng product CARESENG™ containing mainly aPPD induced cell apoptosis through various signal pathways including caspases. CARESENG™ also enhances the sensitivity of multidrug-resistant cancer cells to various chemotherapy drugs. P-glycoprotein (P-gp, MDR1) is one of the major causes of multidrug resistance of many tumor cells. Blocking the function of P-gp may enhance efficacy of chemotherapy. In the present study, we investigated the possible mechanism of chemo sensitizing effect of purified aPPD compound as well as CARESENG. Methods: Breast cancer cell MCF-7adr and leukemia cell line P388adr, both overexpressing P-gp, were used to test the interaction between the compound and P-gp. Calcein-AM, a P-gp substrate, efflux assay was used to measure function of P-gp. Membrane preparation was also used to measure the ATPase activity of P-gp in the presence of aPPD or verapamil. Results: Our results demonstrated that 70uM aPPD could significantly block P-gp function on both MCF-7adr and P388adr cells showing increased intracellular concentrations of calcein-AM. Furthermore, the maximum effects of aPPD and verapamil on P-gp inhibition was additive when treated together on P388adr cells. On the other hand, aPPD had no effect on ATPase activity of P-gp while verapamil increased it by more than 2-fold. 20uM of aPPD completely reversed P-gp induced drug resistant to Taxol or Doxorubicin on MCF-7adr cells. CARESENG™ gave rise to similar results in all the above experiments. Conclusions: These results suggest that aPPD is an effective P-gp blocker with a mechanism different from that of verapamil. Given extremely low toxicity of the compound, aPPD is a potential candidate of chemosensitizer for treatment of multidrug-resistant tumors. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration PanaGin Pharmaceuticals PanaGin Pharmaceuticals PanaGin Pharmaceuticals.
For answers or to make an appointment, call us toll-free at
800-923-7878
Recover your vitality, reclaim your energy and rediscover your health.
