Curcumin inhibits AP-2γ-induced apoptosis in the human malignant testicular germ cells in vitro.
Curcumin dose-dependently induced apoptosis of NTera-2 cells by reducing FasL expression and Bcl-2-to-Bax ratio, and activating caspase-9, -8 and -3.
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Browse 11 source-linked studies with the full title, publication year, research focus and a concise finding. Select any linked substance to move directly to its corresponding Sunridge page.
2013 · Apoptosis and cell death
Curcumin dose-dependently induced apoptosis of NTera-2 cells by reducing FasL expression and Bcl-2-to-Bax ratio, and activating caspase-9, -8 and -3.
2013 · Apoptosis and cell death
Curcumin, bleomycin, and H2O2 caused apoptosis indicated as increases in caspase-3, caspase-8, and caspase-9 activities and Bax and cytoplasmic Cyt-c levels and a decrease in Bcl-2 level.
2012 · Metabolism and redox biology
Curcumin significantly decreased LPO, 8-isoprostane and protein carbonyl content, and TBARS levels increased in cells treated with bleomycin and H2O2.
2012 · Treatment response
Curcumin (20 µM), bleomycin (400 µg/ml) and H2O2 (400 µM) incubation for 24 h decreased the viability of NTera-2 cells, and increased caspase-3, -8 and -9 activities, Bax and cytoplasmic cytochrome c levels and decreased Bcl-2 levels.
2013 · Cancer biology and response
As GSTs are involved in drug resistance mechanisms, we hypothesize that BEP induction of GST expression may lead to the survival of damaged germ cells and the production of abnormal sperm.
2025 · Cancer biology and response
The gene ontologies and pathway enrichment analysis were done for these significant genes in response to identifying and accessing the involvement of these genes in other processes.
2024 · Quality of life and symptoms
Physical activity (PA) has established effects on reducing CRF and other sequelae and improving health-related quality of life (HRQoL).
2023 · Metastasis and invasion
To investigate the effect of rapamycin for enhancing the inhibitory effect of RSL3 on proliferation, invasion and migration of testicular cancer I-10 cells in vitro.
2021 · Cancer biology and response
The study reports correction to: Are serum levels of 25-hydroxy vitamin D reduced following orchiectomy in testicular cancer patients?.
2018 · Cancer biology and response
Patients with testicular cancer have reduced vitamin D levels after the treatment of the primary cancer.
2021 · Cancer biology and response
Loss of one testis was suggested to result in reduced vitamin D serum levels.
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