Testicular Cancer · LIVING RESEARCH LIBRARY

Ongoing Research for Testicular Cancer Using Advanced Alternative Medicine

Explore positive published findings by substance, cancer biology, treatment interaction and quality-of-life outcome.

Every entry includes the original study title, year, concise finding and a direct PubMed link.

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Testicular Cancer

Living research library · positive published findings

Research organized by substance and finding

Browse 11 source-linked studies with the full title, publication year, research focus and a concise finding. Select any linked substance to move directly to its corresponding Sunridge page.

Curcumin inhibits AP-2γ-induced apoptosis in the human malignant testicular germ cells in vitro.

2013 · Apoptosis and cell death

Curcumin dose-dependently induced apoptosis of NTera-2 cells by reducing FasL expression and Bcl-2-to-Bax ratio, and activating caspase-9, -8 and -3.

Open study on PubMed →

Effects of curcumin on bleomycin-induced apoptosis in human malignant testicular germ cells.

2013 · Apoptosis and cell death

Curcumin, bleomycin, and H2O2 caused apoptosis indicated as increases in caspase-3, caspase-8, and caspase-9 activities and Bax and cytoplasmic Cyt-c levels and a decrease in Bcl-2 level.

Open study on PubMed →

Effects of curcumin on bleomycin‑induced oxidative stress in malignant testicular germ cell tumors.

2012 · Metabolism and redox biology

Curcumin significantly decreased LPO, 8-isoprostane and protein carbonyl content, and TBARS levels increased in cells treated with bleomycin and H2O2.

Open study on PubMed →

Synergistic anticancer activity of curcumin and bleomycin: an in vitro study using human malignant testicular germ cells.

2012 · Treatment response

Curcumin (20 µM), bleomycin (400 µg/ml) and H2O2 (400 µM) incubation for 24 h decreased the viability of NTera-2 cells, and increased caspase-3, -8 and -9 activities, Bax and cytoplasmic cytochrome c levels and decreased Bcl-2 levels.

Open study on PubMed →

Selective induction of glutathione S-transferases in round spermatids from the Brown-Norway rat by the chemotherapeutic regimen for testicular cancer.

2013 · Cancer biology and response

As GSTs are involved in drug resistance mechanisms, we hypothesize that BEP induction of GST expression may lead to the survival of damaged germ cells and the production of abnormal sperm.

Open study on PubMed →

Exploring the therapeutic effect of melatonin targeting common biomarkers in testicular germ cell tumor, prostate adenocarcinoma, and male infertility: an integrated biology approach.

2025 · Cancer biology and response

The gene ontologies and pathway enrichment analysis were done for these significant genes in response to identifying and accessing the involvement of these genes in other processes.

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Impact of a one-year supervised physical activity program on long-term cancer-related fatigue and mediating effects of the gut microbiota in metastatic testicular cancer patients: protocol of the prospective multicentre, randomized controlled phase-III STARTER trial.

2024 · Quality of life and symptoms

Physical activity (PA) has established effects on reducing CRF and other sequelae and improving health-related quality of life (HRQoL).

Open study on PubMed →

[Rapamycin enhances inhibitory effect of RSL3 on proliferation, invasion and migration of testicular cancer I-10 cells in vitro].

2023 · Metastasis and invasion

To investigate the effect of rapamycin for enhancing the inhibitory effect of RSL3 on proliferation, invasion and migration of testicular cancer I-10 cells in vitro.

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Correction to: Are serum levels of 25-hydroxy vitamin D reduced following orchiectomy in testicular cancer patients?

2021 · Cancer biology and response

The study reports correction to: Are serum levels of 25-hydroxy vitamin D reduced following orchiectomy in testicular cancer patients?.

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Long term deficiency of vitamin D in germ cell testicular cancer survivors.

2018 · Cancer biology and response

Patients with testicular cancer have reduced vitamin D levels after the treatment of the primary cancer.

Open study on PubMed →

Revised manuscript R2, clean version are serum levels of 25-hydroxy vitamin D reduced following orchiectomy in testicular cancer patients?

2021 · Cancer biology and response

Loss of one testis was suggested to result in reduced vitamin D serum levels.

Open study on PubMed →

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