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Zonulin Profile (Stool)
Mosaic Diagnostics1 test optionFrom $174.30
Zonulin Profile (Stool)
Mosaic DiagnosticsCatalog information reviewed: August 24, 2026 by the Sunridge Medical clinical team.
What this laboratory test evaluates
Elevated fecal levels of ZFP have been associated with metabolic syndrome, obesity, and apparently healthy cigarette smokers. High serum levels of ZFP (antigen) are correlated with abnormal results of the Lactulose Mannitol test; the long-accepted standard for intestinal permeability, but to date no such correlation has been reported with fecal ZFP. Excessive intake of simple sugars, sodium, emulsifiers, microbial transglutaminase (food additive) and nano-particles may also be triggers for increased fecal ZFP and intestinal permeability.
Possible interventions to restore the gastrointestinal mucosal barrier include dietary changes, treatment of dysbiosis, digestive supports and anti-inflammatory supplements; specifically quercetin, vitamin C, curcumin, gamma-linoleic acid, omega-3 fatty acids (EPA, DHA), and aloe vera. Other nutrients such as zinc, beta-carotene, pantothenic acid, and L-glutamine may provide some support for rejuvenation of the mucosal barrier. The use of some probiotics has been shown to reduce serum and fecal zonulin levels, and inulin (about 10 grams per day) lowered serum zonulin after just five days in healthy young subjects.
Consider a Comprehensive Stool Analysis to further investigate potential causes of increased intestinal permeability.
Additional test information
Elevated fecal levels of a zonulin family protein (ZFP) have been associated with metabolic syndrome and obesity; conditions that have been linked to increased intestinal permeability (“leaky gut”). Elevated serum levels of the ZFP antigen have been correlated with results from the established lactulose mannitol test. Definitive research has yet to be published regarding a correlation between fecal ZFP levels and the results of the lactulose mannitol test.
Collection and processing
- Sample type: Stool
- Fasting: No
- Estimated laboratory processing: Results should arrive 10 business days after the lab receives samples.
How Sunridge uses laboratory information
Sunridge considers the medical question, symptoms, history, medications, prior results, and whether the finding could change care before recommending testing. A laboratory result is not interpreted in isolation and does not establish a diagnosis by itself.
Before requesting this test
Availability, collection requirements, eligibility, and processing estimates can change. Sunridge reviews each request and, when appropriate, creates the order through Fullscript. Follow the current instructions supplied with the approved order.
Related Sunridge care
Learn how Sunridge approaches Digestive Conditions and ask whether this test is appropriate for your clinical question.
Common questions about this laboratory test
- What sample does this test require?
- The listed sample type is Stool. Confirm current collection instructions in the approved order.
- Does this test require fasting?
- The current catalog record lists fasting as: No. Follow the instructions supplied with the approved order.
- How long does laboratory processing usually take?
- Results should arrive 10 business days after the lab receives samples.. Timing can change after collection or if a laboratory requires additional review.
About this test
Elevated fecal levels of ZFP have been associated with metabolic syndrome, obesity, and apparently healthy cigarette smokers. High serum levels of ZFP (antigen) are correlated with abnormal results of the Lactulose Mannitol test; the long-accepted standard for intestinal permeability, but to date no such correlation has been reported with fecal ZFP. Excessive intake of simple sugars, sodium, emulsifiers, microbial transglutaminase (food additive) and nano-particles may also be triggers for increased fecal ZFP and intestinal permeability.
Possible interventions to restore the gastrointestinal mucosal barrier include dietary changes, treatment of dysbiosis, digestive supports and anti-inflammatory supplements; specifically quercetin, vitamin C, curcumin, gamma-linoleic acid, omega-3 fatty acids (EPA, DHA), and aloe vera. Other nutrients such as zinc, beta-carotene, pantothenic acid, and L-glutamine may provide some support for rejuvenation of the mucosal barrier. The use of some probiotics has been shown to reduce serum and fecal zonulin levels, and inulin (about 10 grams per day) lowered serum zonulin after just five days in healthy young subjects.
Consider a Comprehensive Stool Analysis to further investigate potential causes of increased intestinal permeability.
Additional details
Elevated fecal levels of a zonulin family protein (ZFP) have been associated with metabolic syndrome and obesity; conditions that have been linked to increased intestinal permeability (“leaky gut”). Elevated serum levels of the ZFP antigen have been correlated with results from the established lactulose mannitol test. Definitive research has yet to be published regarding a correlation between fecal ZFP levels and the results of the lactulose mannitol test.
Highlighted health areas
- Gastrointestinal
Biomarkers and report focus
The exact analytes and report format can change. Confirm the current contents in the Fullscript order before payment.
- Zonulin