Curcumin Inhibits the Growth and Metastasis of Melanoma via miR-222-3p/SOX10/Notch Axis.
Curcumin could inhibit the proliferation, migration, and invasion of melanoma cells.
Melanoma · LIVING RESEARCH LIBRARY
Ongoing Research for Melanoma Using Advanced Alternative Medicine
Explore positive published findings by substance, cancer biology, treatment interaction and quality-of-life outcome.
Every entry includes the original study title, year, concise finding and a direct PubMed link.
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Research organized by substance and finding
Browse 26 source-linked studies with the full title, publication year, research focus and a concise finding. Select any linked substance to move directly to its corresponding Sunridge page.
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Engineering endoplasmic reticulum targeted metal-polyphenol curcumin nanomicelles for melanoma therapy.
Functionally, TCPC significantly suppresses cell viability, migration, and invasion in vitro.
Antitumor/anti-angiogenesis efficacy of epigallocatechin gallate nanoformulated with antioxidant in melanoma.
Nano-EGCG formulations had enhanced stability and produced greater suppression of melanoma tumor growth and angiogenesis compared with free EGCG.
Abemaciclib induces G1 arrest and lysosomal dysfunction in canine melanoma cells: synergistic effects with fenbendazole.
In vivo, abemaciclib alone or in combination with fenbendazole significantly suppressed tumor growth.
Organogermanium THGP Induces Differentiation into M1 Macrophages and Suppresses the Proliferation of Melanoma Cells via Phagocytosis
Organogermanium THGP promoted M1 macrophage polarization and increased macrophage-associated suppression of melanoma-cell proliferation.
Ginseng-derived nanoparticles alter macrophage polarization to inhibit melanoma growth.
GDNPs can alter M2 polarization both in vitro and in vivo, which contributes to an antitumor response.
Ginsenoside Re inhibits melanogenesis and melanoma growth by downregulating microphthalmia-associated transcription factor.
Among them, one notable ginsenoside called Re has shown various biological effects, including anti-cancer and anti-inflammatory properties.
Ginsenoside Rg3 inhibits melanoma progression by inducing ferroptosis via the p53/SLC7A11/GPX4 pathway.
Ginsenoside Rg3, an active component extracted from the roots of Panax ginseng, has been extensively demonstrated to possess significant anti-tumor efficacy, showing promising application potential in the treatment of various malignancies.
Microsomal glutathione transferase 1 controls metastasis and therapeutic response in melanoma.
When compared to control, mice bearing Mgst1 KD B16 tumors had more CD8+ T cell infiltration with reduced expression of inhibitory receptors and increased cytokine response, large reduction of lung metastases and enhanced survival.
Inositol hexaphosphate (IP6) inhibits cellular proliferation in melanoma.
Our findings that IP6 significantly decreased cellular growth, VEGF production and increased late apoptosis in melanoma suggest its potential therapeutic value.
Drug repurposing of ivermectin abrogates neutrophil extracellular traps and prevents melanoma metastasis.
We identified ivermectin (IVM), a widely used antiparasitic drug, significantly inhibits neutrophil extracellular traps (NETs) formation after cathepsin B (CTSB) treatment.
Melatonin and Metformin Failed to Modify the Effect of Dacarbazine in Melanoma.
Current data support the possibility of antitumor activity of melatonin and metformin.
Melatonin Receptor Expression in Primary Uveal Melanoma.
Melatonin, noted for its anti-cancer properties in various malignancies, including cutaneous melanoma, shows promise in Uveal melanoma (UM) treatment.
Ozonated olive oil inhibits melanoma proliferation by inducing ferroptosis.
Treatment with OZO markedly inhibited the proliferation of both human and murine melanoma cells, while sparing normal human keratinocyte.
Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response.
Higher dietary fiber was associated with significantly improved progression-free survival in 128 patients on ICB, with the most pronounced benefit observed in patients with sufficient dietary fiber intake and no probiotic use.
Dysbiosis of skin microbiome and gut microbiome in melanoma progression.
The microbiome alterations are associated with cancer growth and may influence the immune system and response to therapy.
Integration of donor microbiota following FMT correlates with anti-PD-1 response in melanoma.
Together these findings highlight that distinct patterns of microbiome restructuring, including stable community transitions and altered functional capacity, are associated with anti-PD-1 response following FMT.
Longitudinal analysis of the gut microbiota during anti-PD-1 therapy reveals stable microbial features of response in melanoma patients.
Varying patient responses were linked to different gut microbiota dynamics during ICI treatment.
Unbiased Microbiome and Metabolomic Profiling of Fecal Samples from Patients with Melanoma.
In preclinical cancer models, mice lacking gut microbiota have a markedly diminished response to immune checkpoint inhibitor therapy.
Quercetin Induces Mitochondrial Apoptosis and Downregulates Ganglioside GD3 Expression in Melanoma Cells.
Moreover, our investigation indicates that quercetin significantly reduces the expression levels of ganglioside GD3 and its synthetic enzyme.
Quercetin Mediated TET1 Expression Through MicroRNA-17 Induced Cell Apoptosis in Melanoma Cells.
In addition, quercetin treatment induced apoptosis and inhibited migration and invasion.
Resveratrol-loaded nanocapsules inhibit murine melanoma tumor growth.
There was a decrease in tumor volume, an increase in the necrotic area and inflammatory infiltrate of melanoma when resveratrol-loaded nanocapsules were compared to free resveratrol in treated mice.
Resveratrol: A New Potential Therapeutic Agent for Melanoma?
Resveratrol, known as a polyphenol component present in grapes and some plants, has anti-cancer properties due to its function as an apoptosis inducer in tumor cells, and anti-angiogenic agent to prevent metastasis.
Ascorbate induces apoptosis in melanoma cells by suppressing Clusterin expression.
Here we show that 100 µM of ascorbate induced apoptosis in A2058 melanoma cells.
Vitamin C Sensitizes Melanoma to BET Inhibitors.
Cotreatment with ascorbate and JQ1 induced apoptosis and inhibited proliferation of cultured melanoma cells.
Inhibition of the RIPK4 enhances suppression of human melanoma growth through vitamin D signaling.
The active form of vitamin D3 (1,25-D3), in addition to regulating calcium and phosphate metabolism in humans through the vitamin D receptor (VDR), can inhibit the NF-κB signaling pathway and can affect the proliferation and differentiation of normal and malignant cells, including melanoma.
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