Berberine enhances the sensitivity of radiotherapy in ovarian cancer cell line (SKOV-3).
Berberine, a well-known isoquinoline alkaloid derivative, has a varied range of pharmacological effects.
Ovarian Cancer · LIVING RESEARCH LIBRARY
Ongoing Research for Ovarian Cancer Using Advanced Alternative Medicine
Explore positive published findings by substance, cancer biology, treatment interaction and quality-of-life outcome.
Every entry includes the original study title, year, concise finding and a direct PubMed link.
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Research organized by substance and finding
Browse 23 source-linked studies with the full title, publication year, research focus and a concise finding. Select any linked substance to move directly to its corresponding Sunridge page.
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Berberine modulates ovarian cancer autophagy and glycolysis through the LINC01123/P65/MAPK10 signaling axis.
The anti-proliferative and anti-metastatic effects of berberine on ovarian cancer cells were investigated using CCK-8 assays, scratch assays, EDU proliferation assays, and assays related to glycolysis and autophagy.
Curcumin derivative NL01 induces ferroptosis in ovarian cancer cells via HCAR1/MCT1 signaling.
CCK-8 was used to detect curcumin and derivative IC50, crystalline violet staining was used to detect the proliferation inhibition effect of NL01 in ovarian cancer, western blot and qPCR were used to detect downstream related molecular expression changes, Transwell and survival curve assays were used to detect malignant phenotypic.
Curcumin induces ferroptosis in ovarian cancer cells through the Nrf2/GPX4 regulation axis.
Our results demonstrated that curcumin inhibited proliferation, migration, and invasion of SK-OV-3 and A2780 cells in a dose-dependent manner, while inducing apoptosis and ferroptosis, as evidenced by elevated reactive oxygen species (ROS), MDA, Fe2+ levels, and depletion of GSH.
Curcumin inhibits ovarian cancer progression by regulating circ-PLEKHM3/miR-320a/SMG1 axis.
Circ-PLEKHM3 overexpression exacerbated the effect of curcumin on ovarian cancer cell proliferation and apoptosis, as well as anti-tumor effect.
Curcuminoids WM03 inhibits ovarian cancer cisplatin-resistant cells proliferation and reverses cisplatin resistance by targeting DYRK2.
Curcumin has been shown to effectively inhibit the proliferation and invasion of ovarian cancer cells but its bioavailability restricts its application.
RETRACTION NOTICE: Curcumin and resveratrol inhibit chemoresistance in cisplatin-resistant epithelial ovarian cancer cells via targeting P13K pathway.
The study reports rETRACTION NOTICE: Curcumin and resveratrol inhibit chemoresistance in cisplatin-resistant epithelial ovarian cancer cells via targeting P13K pathway.
Anti-cancer effect of fenbendazole-incorporated PLGA nanoparticles in ovarian cancer.
Fenbendazole (FZ) has potential anti-cancer effects, but its poor water solubility limits its use for cancer therapy.
Transcriptome analysis reveals the anticancer effects of fenbendazole on ovarian cancer: an in vitro and in vivo study.
Here, we investigated the anticancer effects of fenbendazole (FBZ), a benzimidazole compound, on the regulation of apoptosis and mitotic catastrophe in A2780 and SKOV3 human epithelial ovarian cancer cells.
Ginsenoside 20(S)-Rg3 upregulates SQLE to reprogram cholesterol metabolism of ovarian cancer cells.
Silencing of SQLE attenuated the inhibitory effects of 20(S)-Rg3 on ovarian cancer cell proliferation in vitro and in vivo, as well as cell migration, invasion, and cholesterol synthesis.
Ivermectin Augments the Anti-Cancer Activity of Pitavastatin in Ovarian Cancer Cells.
When the drugs were combined and assessed in cell growth assays, ivermectin showed synergy with pitavastatin in 3 cell lines and this was most evident in COV-318 cells (combination index ~ 0.6).
Melatonin changes energy metabolism and reduces oncogenic signaling in ovarian cancer cells.
Because melatonin (Mel) has antitumor actions, we investigated its impact on energy metabolism and kinase signaling in OC cells (SKOV-3 and CAISMOV-24).
The proteomic landscape of ovarian cancer cells in response to melatonin.
We conclude that melatonin significantly alters the proteome of SKOV-3 cells by changing proteins involved with the immune response and mitochondrial metabolism.
Association between vaginal microbiota and the progression of ovarian cancer.
Local therapeutic intervention with a broad spectrum of antibiotics was effective in reversing microbiota dysbiosis and suppressing carcinogenic progression.
Disruption of the Gut Microbiota Confers Cisplatin Resistance in Epithelial Ovarian Cancer.
Cecal transplants of microbiota derived from control-treated mice was sufficient to ameliorate chemoresistance and prolong survival of ABX-treated mice, indicative of a gut-derived tumor suppressor.
Potential role of microbiota in ovarian cancer treatment.
Recent research indicates that gut, vaginal, and uterine microbiota play a critical role in the response to treatments of ovarian cancer, and particularly in chemotherapy, anti-angiogenic therapy, and PARP inhibitors.
Unintended Consequences of Antibiotic Therapy on the Microbiome Delivers a Gut Punch in Ovarian Cancer.
The study by Chambers and colleagues in this issue of Cancer Research provides mechanistic insights into how disrupting the gut microbiome with broad-spectrum antibiotics negatively influences the survival of patients with ovarian cancer and highlights the impact of the gut microbiome on tumor progression and response to therapy.
Identification of Quercetin as a Natural MMP1 Inhibitor for Overcoming Cisplatin Resistance in Epithelial Ovarian Cancer.
In vitro experiments demonstrated that quercetin effectively inhibited the proliferation, apoptosis resistance, invasion, and migration of cisplatin-resistant EOC cells.
Quercetin combined with shTERT induces apoptosis in ovarian cancer via the P53/Bax pathway, and RGD-MSN/QR/shTERT nanoparticles enhance the therapeutic efficacy.
Quercetin(QR) has been shown to inhibit the cell cycle and induce the apoptosis in various types of tumors.
Quercetin induces ferroptosis in ovarian cancer through regulating HSPB1/Notch1 pathway.
Quercetin inhibited cell proliferation and colony formation, triggered apoptosis, and promoted ferroptosis in A2780 and SKOV3 cells, marked by GPX4 downregulation and malondialdehyde levels increase.
The impact of quercetin and paclitaxel combination on ovarian cancer cells.
This study investigated the synergistic effects of quercetin and paclitaxel on ovarian cancer.
Resveratrol reduces lactate production and modifies the ovarian cancer immune microenvironment.
Significantly, combined resveratrol and PD-1 blockade promote anti-tumor efficacy.
Silybin suppresses ovarian cancer cell proliferation by inhibiting isocitrate dehydrogenase 1 activity.
Here, we report that Silybin (a nontoxic flavonoid commonly used for liver protection) exhibits prominent anti-tumor effects on human ovarian cancer cells.
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