Endometrial Carcinoma and Uterine Sarcoma Are Not the Same Disease
Endometrial carcinoma begins in the lining of the uterus and accounts for most uterine cancers. Uterine sarcomas arise from muscle or connective tissue and are uncommon. Their pathology, staging, expected behavior and treatment can differ substantially, so expert pathology review is especially valuable when the diagnosis is rare or uncertain.
Endometrioid Carcinoma
This is the most common subtype. Grade, depth of myometrial invasion, lymphovascular invasion, stage and molecular class all influence risk.
Serous, Clear Cell and Carcinosarcoma
These cancers can behave more aggressively. Selected uterine serous cancers should be assessed for HER2 because it may create a targeted-treatment option.
Uterine Sarcoma
Leiomyosarcoma, endometrial stromal sarcoma and other sarcomas need their own expert treatment pathway rather than an endometrial-cancer template.
Think About Lynch Syndrome
Mismatch-repair testing helps guide immunotherapy and can identify patients who should discuss germline testing for Lynch syndrome.

