Symptoms of Lichen Planus
We offer breakthrough lichen planus treatment at Sunridge Medical. Symptoms include rashes on the lower back, inner wrists, forearms, and ankles which may appear gradually and spread over months or come on suddenly. Purple or pink lesions may appear on the skin and mucus membrane connected by fine white lines. These blisters are often uncomfortable and may cause itching, particularly at night. Lichen Planus can also cause loss of hair and nails.
Lichen Planus is an autoimmune disease affecting the skin, eyes, lining of the mouth, and genitalia caused by an abnormal immune reaction. The body’s white blood cells mistake the body’s skin for a foreign entity and attack it causing blister-like lesions to form on the skin and mucous membrane, usually clearing within eighteen months.
Lichen Planus affects more women than men and occurs most often in middle age. It is very rare in children. The development of the disease can be slow and is often diagnosed with other autoimmune diseases present in the body. The cause is unknown though there have been links found between Lichen Planus and a high-stress lifestyle.
References on Lichen Planus
Turmeric is dried rhizome of the perennial herbs curcumalonga. It is called Haldi in Hindi, turmeric in English, ukon in Japanese. It has been used in Asian Medicine since the second millennium BC. Its utility is referred to in the ancient Hindu script the Ayurveda.
Pathogenesis of the OLP should be taken in consideration for the treatment point of view. The Cell-mediated immunity to secondary antigenic change in oral mucous membrane is thought to play a major role in its pathogenesis modified keratocyte surface antigens are the primary target for cytotoxic cellular response. Curcumin also been shown to have immune modulatory effect involving activation of host macrophages and natural killer cells and modulation of lymphocytes mediated function.
Jajarm HH, Falaki F, Mahdavi O. A comparative pilot study of low-intensity laser versus topical corticosteroids in the treatment of erosive-atrophic oral lichen planus. Photomed Laser Surg. 2011 Jun;29(6):421-5. doi: 10.1089/pho.2010.2876. Epub 2011 Jan 8. PMID: 21214369. https://pubmed.ncbi.nlm.nih.gov/21214369/
Background and objective: Treatment of oral lichen planus (OLP) remains a great challenge for clinicians. The aim of our study was to compare the effect of low-intensity laser therapy (LILT) with topical corticosteroids in the treatment of oral erosive and atrophic lichen planus.
Materials and methods: Thirty patients with erosive-atrophic OLP were randomly allocated into two groups. The experimental group consisted of patients treated with the 630 nm diode laser. The control group consisted of patients who used Dexamethason mouth wash. Response rate was defined based on changes in the appearance score and pain score (Visual Analogue Scale) of the lesions before and after each treatment.
Results: Appearance score, pain score, and lesion severity were reduced in both groups. No significant differences were found between the treatment groups regarding the response rate and relapse.
Conclusion: Our study demonstrated that LILT was as effective as topical corticosteroid therapy without any adverse effects and it may be considered as an alternative treatment for erosive-atrophic OLP in the future.
Sharma C, Kaur J, Shishodia S, Aggarwal BB, Ralhan R. Curcumin down regulates smokeless tobacco-induced NF-kappaB activation and COX-2 expression in human oral premalignant and cancer cells. Toxicology. 2006 Nov 10;228(1):1-15. doi: 10.1016/j.tox.2006.07.027. Epub 2006 Aug 12. PMID: 16996673.
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