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Celiac, IBS, and Crohn's Assay (CICA)
Cell Science Systems1 test optionFrom $627.90
Celiac, IBS, and Crohn's Assay (CICA)
Cell Science SystemsWhat this laboratory test evaluates
The Celiac, IBS, and Crohn's Assay (CICA) is a comprehensive test array that analyzes genetic predisposition, detects specific antibodies, and measures potentially inflammatory cellular reactions all through one simple blood draw. Celiac disease risk analysis is determined based on the presence or absence of the HLA-DQ genotypes. Both the DQ8 and DQ2.5 genotypes are tested in this array, with the DQ2.5 genotypes representing a much greater risk of celiac disease. Four specific serum antibodies (DGP IgG/IgA and tTG IgG/IgA) are tested due to their high sensitivity and specificity for active celiac disease. The higher the antibody levels, the more likely untreated celiac disease is present. Genetic markers, mutations in the ATG16L1 and NOD2 genes, associated with the Crohn’s disease are tested along with serologic markers for complete assessment. Anti-Saccharomyces Cerevisiae Antibody (ASCA; IgG/IgA) are immune proteins that are frequently present in people who have Crohn’s disease. The presence of ASCA may also reflect increased intestinal inflammation and permeability, including an association with active Crohn’s disease.
Additional test information
The Celiac, IBS, and Crohn's Assay (CICA) evaluates genetic and serological markers for celiac disease and Crohn's disease.
Collection and processing
- Sample type: Serum, Whole blood
- Fasting: No
- Estimated laboratory processing: Results should arrive 10 business days after the lab receives samples.
How Sunridge uses laboratory information
Sunridge considers the medical question, symptoms, history, medications, prior results, and whether the finding could change care before recommending testing. A laboratory result is not interpreted in isolation and does not establish a diagnosis by itself.
Before requesting this test
Availability, collection requirements, eligibility, and processing estimates can change. Sunridge reviews each request and, when appropriate, creates the order through Fullscript. Follow the current instructions supplied with the approved order.
Related Sunridge care
Learn how Sunridge approaches Autoimmune Diseases, Digestive Conditions and ask whether this test is appropriate for your clinical question.
About this test
The Celiac, IBS, and Crohn's Assay (CICA) is a comprehensive test array that analyzes genetic predisposition, detects specific antibodies, and measures potentially inflammatory cellular reactions all through one simple blood draw. Celiac disease risk analysis is determined based on the presence or absence of the HLA-DQ genotypes. Both the DQ8 and DQ2.5 genotypes are tested in this array, with the DQ2.5 genotypes representing a much greater risk of celiac disease. Four specific serum antibodies (DGP IgG/IgA and tTG IgG/IgA) are tested due to their high sensitivity and specificity for active celiac disease. The higher the antibody levels, the more likely untreated celiac disease is present. Genetic markers, mutations in the ATG16L1 and NOD2 genes, associated with the Crohn’s disease are tested along with serologic markers for complete assessment. Anti-Saccharomyces Cerevisiae Antibody (ASCA; IgG/IgA) are immune proteins that are frequently present in people who have Crohn’s disease. The presence of ASCA may also reflect increased intestinal inflammation and permeability, including an association with active Crohn’s disease.
Additional details
The Celiac, IBS, and Crohn's Assay (CICA) evaluates genetic and serological markers for celiac disease and Crohn's disease.
Highlighted health areas
- Autoimmune
- Genetics
- Gastrointestinal
Biomarkers and report focus
The exact analytes and report format can change. Confirm the current contents in the Fullscript order before payment.
- Tissue Transglutaminase (tTG) Antibody (IgA)
- Immunoglobulin A (IgA)
- Deamidated gliadin peptide (DGP) IgA
- Deamidated gliadin peptide (DGP) IgG
- Tissue Transglutaminase (tTG) Antibody (IgG)
- Saccharomyces cerevisiae IgG
- ATG16L1 (T300A)
- HLA-DQA1*03
- HLA-DQA1*05
- HLA-DQB1*02
- HLA-DQB1*03:02
- NOD2 (G908R)
- NOD2 (L1007fsinsC)
- NOD2 (R702W)
- Saccharomyces cerevisiae IgA