Compare this test’s laboratory options
Chromatin
Quest Diagnostics1 test optionFrom $81.67
Chromatin
Quest DiagnosticsCatalog information reviewed: August 24, 2026 by the Sunridge Medical clinical team.
What this laboratory test evaluates
Chromatin (Nucleosomal) Antibody
This test is crucial for understanding the autoimmune response in systemic lupus erythematosus (SLE), a condition where the body's immune system mistakenly attacks its own tissues. About 90% of people with SLE show positive results for this test, indicating their immune system is reacting to nucleosomes, which are components of the cell's nucleus.
What patients is this test right for?This test is particularly important for individuals suspected of having SLE, given its high reactivity rate in those diagnosed with the condition.
Symptoms of SLE can vary widely but often include: • Joint pain and swelling
• Skin rashes, particularly those that worsen with sun exposure
• Fatigue
• Fever
• Chest pain when breathing deeply
• Headaches, confusion, and memory loss
What type of sample is required for this test?1 mL serum.
Test ResourcesInformation on this test is currently being updated. Please consult your healthcare provider for more details.
Additional test information
Chromatin (Nucleosomal) Antibody – This test is crucial for understanding the autoimmune response in systemic lupus erythematosus (SLE), a condition where the body's immune system mistakenly attacks its own tissues. About 90% of people with SLE show positive results for this test, indicating their immune system is reacting to nucleosomes, which are components of the cell's nucleus.
Collection and processing
- Sample type: Serum
- Fasting: No
- Estimated laboratory processing: Results should be available in 2 – 5 business days after the sample is collected
How Sunridge uses laboratory information
Sunridge considers the medical question, symptoms, history, medications, prior results, and whether the finding could change care before recommending testing. A laboratory result is not interpreted in isolation and does not establish a diagnosis by itself.
Before requesting this test
Availability, collection requirements, eligibility, and processing estimates can change. Sunridge reviews each request and, when appropriate, creates the order through Fullscript. Follow the current instructions supplied with the approved order.
Common questions about this laboratory test
- What sample does this test require?
- The listed sample type is Serum. Confirm current collection instructions in the approved order.
- Does this test require fasting?
- The current catalog record lists fasting as: No. Follow the instructions supplied with the approved order.
- How long does laboratory processing usually take?
- Results should be available in 2 – 5 business days after the sample is collected. Timing can change after collection or if a laboratory requires additional review.
About this test
Chromatin (Nucleosomal) Antibody
This test is crucial for understanding the autoimmune response in systemic lupus erythematosus (SLE), a condition where the body's immune system mistakenly attacks its own tissues. About 90% of people with SLE show positive results for this test, indicating their immune system is reacting to nucleosomes, which are components of the cell's nucleus.
What patients is this test right for?This test is particularly important for individuals suspected of having SLE, given its high reactivity rate in those diagnosed with the condition.
Symptoms of SLE can vary widely but often include: • Joint pain and swelling
• Skin rashes, particularly those that worsen with sun exposure
• Fatigue
• Fever
• Chest pain when breathing deeply
• Headaches, confusion, and memory loss
What type of sample is required for this test?1 mL serum.
Test ResourcesInformation on this test is currently being updated. Please consult your healthcare provider for more details.
Additional details
Chromatin (Nucleosomal) Antibody - This test is crucial for understanding the autoimmune response in systemic lupus erythematosus (SLE), a condition where the body's immune system mistakenly attacks its own tissues. About 90% of people with SLE show positive results for this test, indicating their immune system is reacting to nucleosomes, which are components of the cell's nucleus.
Highlighted health areas
- Autoimmune
Biomarkers and report focus
The exact analytes and report format can change. Confirm the current contents in the Fullscript order before payment.
- Chromatin (Nucleosomal) Antibody