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Fecal Gluten Peptide (Stand-Alone)
Diagnostic Solutions Laboratory1 test optionFrom $170.48
Fecal Gluten Peptide (Stand-Alone)
Diagnostic Solutions LaboratoryWhat this laboratory test evaluates
Detect Exposure to Gluten for Better Dietary Management
Gluten Peptide is commonly present in stool. Gluten-containing grains (such as wheat, rye, barley, and oat*) are digested into their gliadin and glutenin subunits. A specific section of the gliadin protein, referred to as the 33-mer peptide, is resistant to digestion in the human gastrointestinal (GI) tract and functions as a significant immune trigger in certain individuals, including those with celiac disease (CD).1 Even in non-celiac gluten-sensitive (NCGS) individuals, the 33-mer protein can be antigenic, inducing food sensitivities and intestinal permeability (leaky gut). When intestinal permeability is present, this antigenic peptide can drive extra-intestinal symptoms – those presenting outside the GI tract – such as skin manifestations, headaches, behavioral symptoms, and more. This test is a direct quantification of the 33-mer gliadin peptide present in stool samples. Because this peptide is highly resistant to human digestion, it can be accurately detected in a person's stool several days after consumption of gluten. The Gluten Peptide (Stool Gluten) marker can be ordered as an add-on to the GI-MAP in the Results Portal.The Benefits of Quantitatively Assessing Gluten in Stool
Currently, the only approach to managing celiac disease is to maintain a strict gluten-free (GF) diet for life. Additionally, as non-celiac gluten-related disorders are emerging more and more in literature and clinical practice, many people choose to be gluten-free to reduce GI inflammation and associated symptoms, and to prevent or heal intestinal permeability. Although conceptually straight forward, there are inherent challenges to following a GF diet as recommended. Estimated compliance rates vary considerably. The importance of monitoring a GF diet is obvious, however there are currently no clear guidelines for exploring adherence or assessing the outcome. Recent studies suggest that patients cannot rely on dietary best practices or even symptoms to understand if they have been exposed to gluten.
The Fecal Gluten Peptide Add-On (Stool Gluten) is an accurate and noninvasive method that enables a direct, quantitative assessment of gluten consumption. The amount of gluten peptide detected in stool rises in proportion to the amount of gluten consumed. Thus, the test can be useful for monitoring occasional exposures or exposures that may be routine in a persons' lifestyle (even if they are unknown).
Fecal gluten monitoring is an important tool to: • Monitor adherence to gluten-free diet for anyone aiming to follow a GF lifestyle
• Monitor accidental (unintentional) consumption of gluten for both the celiac and non-celiac gluten sensitive patient, even if they are not experiencing symptoms
• Assist in the assessment of refractory celiac (failure to heal despite going GF)
Additional test information
This test is a direct quantification of the 33-mer gliadin peptide present in stool samples. Because this peptide is highly resistant to human digestion, it can be accurately detected in a person's stool several days after consumption of gluten.
Collection and processing
- Sample type: Stool
- Fasting: No
- Estimated laboratory processing: Results should arrive 7 – 14 business days after the lab receives samples.
How Sunridge uses laboratory information
Sunridge considers the medical question, symptoms, history, medications, prior results, and whether the finding could change care before recommending testing. A laboratory result is not interpreted in isolation and does not establish a diagnosis by itself.
Before requesting this test
Availability, collection requirements, eligibility, and processing estimates can change. Sunridge reviews each request and, when appropriate, creates the order through Fullscript. Follow the current instructions supplied with the approved order.
Related Sunridge care
Learn how Sunridge approaches Digestive Conditions and ask whether this test is appropriate for your clinical question.
About this test
Detect Exposure to Gluten for Better Dietary Management
Gluten Peptide is commonly present in stool. Gluten-containing grains (such as wheat, rye, barley, and oat*) are digested into their gliadin and glutenin subunits. A specific section of the gliadin protein, referred to as the 33-mer peptide, is resistant to digestion in the human gastrointestinal (GI) tract and functions as a significant immune trigger in certain individuals, including those with celiac disease (CD).1 Even in non-celiac gluten-sensitive (NCGS) individuals, the 33-mer protein can be antigenic, inducing food sensitivities and intestinal permeability (leaky gut). When intestinal permeability is present, this antigenic peptide can drive extra-intestinal symptoms – those presenting outside the GI tract – such as skin manifestations, headaches, behavioral symptoms, and more. This test is a direct quantification of the 33-mer gliadin peptide present in stool samples. Because this peptide is highly resistant to human digestion, it can be accurately detected in a person's stool several days after consumption of gluten. The Gluten Peptide (Stool Gluten) marker can be ordered as an add-on to the GI-MAP in the Results Portal.The Benefits of Quantitatively Assessing Gluten in Stool
Currently, the only approach to managing celiac disease is to maintain a strict gluten-free (GF) diet for life. Additionally, as non-celiac gluten-related disorders are emerging more and more in literature and clinical practice, many people choose to be gluten-free to reduce GI inflammation and associated symptoms, and to prevent or heal intestinal permeability. Although conceptually straight forward, there are inherent challenges to following a GF diet as recommended. Estimated compliance rates vary considerably. The importance of monitoring a GF diet is obvious, however there are currently no clear guidelines for exploring adherence or assessing the outcome. Recent studies suggest that patients cannot rely on dietary best practices or even symptoms to understand if they have been exposed to gluten.
The Fecal Gluten Peptide Add-On (Stool Gluten) is an accurate and noninvasive method that enables a direct, quantitative assessment of gluten consumption. The amount of gluten peptide detected in stool rises in proportion to the amount of gluten consumed. Thus, the test can be useful for monitoring occasional exposures or exposures that may be routine in a persons' lifestyle (even if they are unknown).
Fecal gluten monitoring is an important tool to: • Monitor adherence to gluten-free diet for anyone aiming to follow a GF lifestyle
• Monitor accidental (unintentional) consumption of gluten for both the celiac and non-celiac gluten sensitive patient, even if they are not experiencing symptoms
• Assist in the assessment of refractory celiac (failure to heal despite going GF)
Additional details
This test is a direct quantification of the 33-mer gliadin peptide present in stool samples. Because this peptide is highly resistant to human digestion, it can be accurately detected in a person's stool several days after consumption of gluten.
Highlighted health areas
- Gastrointestinal
Biomarkers and report focus
The exact analytes and report format can change. Confirm the current contents in the Fullscript order before payment.
- 33-mer gliadin peptide