Hepatic Detox Profile

Catalog information reviewed: August 24, 2026 by the Sunridge Medical clinical team.

What this laboratory test evaluates

The production, use and disposal of toxic chemicals and synthetic materials have increased the risk of exposure to health-threatening toxins. Causal relationships between toxic chemicals and diseases have been well established. However many patients endure chronic symptoms that are associated with exposure to toxins before advanced stages of specific diseases are realized. Thus, there is a great demand for noninvasive laboratory tests that can provide timely assessment of chemical exposure and the capability of hepatic detoxification.

One process by which the body eliminates toxins is enzymatic detoxification in the liver. A reliable biomarker for exposure to toxic chemicals is urinary D-glucaric acid. Elevated levels of D-glucaric acid indicate induction of cytochrome P-450 enzymes (phase I) as a result of exposure to many xenobiotics, including pesticides, fungicides, petrochemicals, drugs, toluene, formaldehyde, styrenes and more. Such exposures induce the glucuronic acid enzymatic pathway and production of D-glucaric acid, thus urinary D-glucaric acid is an indirect byproduct of chemical exposure and phase I detoxification reactions.

The urinary level of mercapturic acids indicates quantitatively the degree of activity or capability of phase II detoxification. Mercapturic acids are the final excretory products of detoxification and include a variety of functionalized xenobiotics that have been conjugated with glutathione or L-cysteine prior to excretion. Low levels of mercapturic acids are consistent with insufficient levels of glutathione and/or cysteine. When the rate of formation of functionalized xenobiotics (phase I) exceeds the capacity of phase II detoxification, more potent toxins accumulate.

Especially important for symptomatic patients or those who have a history of chemical sensitivity, this test does not require the use of hepatotoxic compounds. This non-invasive test requires only a single, first morning void (FMV) urine collection. Results are expressed per unit creatinine to normalize for dilution effects, and reference ranges are age and gender specific. The test does not replace comprehensive liver tests for cases of advanced liver disease.

Additional test information

The body continually attempts to eliminate chemical toxins through enzymatic processes in the liver. Urinary D-glucaric acid, a byproduct of Phase I detoxification, is an indicator of chemical exposure to over 200 chemicals. Urinary mercapturic acids are excreted end products of Phase II detoxification. Together, assessment of these two analytes provides valuable information about exposure to xenobiotics, liver disease and the ability of the liver to eliminate toxins. This non-invasive test requires a single, first morning void (FMV) urine collection.

Collection and processing

• Sample type: Urine
• Fasting: No
• Estimated laboratory processing: Results should arrive 5 to 7 days after the lab receives samples.

How Sunridge uses laboratory information

Sunridge considers the medical question, symptoms, history, medications, prior results, and whether the finding could change care before recommending testing. A laboratory result is not interpreted in isolation and does not establish a diagnosis by itself.

Before requesting this test

Availability, collection requirements, eligibility, and processing estimates can change. Sunridge reviews each request and, when appropriate, creates the order through Fullscript. Follow the current instructions supplied with the approved order.