Compare this test’s laboratory options
Histamine Intolerance Test
Cell Science Systems1 test optionFrom $417.90
Histamine Intolerance Test
Cell Science SystemsWhat this laboratory test evaluates
Histamine is a bioactive molecule that functions as an important neurotransmitter and inflammatory mediator. Histamine intolerance occurs when there is an imbalance between histamine accumulation and the body’s ability to break it down. Histamine intolerance is mainly caused by low levels of an enzyme called DAO. This enzyme helps break down histamine in the digestive system. When there isn’t enough DAO, histamine builds up and causes symptoms. Some individuals inherit genetic variations that reduce their ability to produce adequate amounts of DAO enzyme or affect how efficiently the enzyme functions. Conditions such as SIBO (small intestinal bacterial overgrowth), IBS (irritable bowel syndrome), IBD (inflammatory bowel disease), celiac disease, and gut permeability (leaky gut) can damage intestinal cells that produce DAO enzymes, leading to excess histamine. Certain drugs including some antibiotics, anti-depressants, and pain relievers can block DAO activity or release histamine from cells. Consuming excessive amounts of histamine-rich foods can overwhelm even normal DAO levels, temporarily creating intolerance symptoms.
Additional test information
This test analyzes genetic SNPs in the DAO (AOC1) gene that may affect the body's ability to break down histamine in the gut.
Collection and processing
- Sample type: Buccal swab
- Fasting: No
- Estimated laboratory processing: Results should arrive 10 business days after the lab receives samples.
How Sunridge uses laboratory information
Sunridge considers the medical question, symptoms, history, medications, prior results, and whether the finding could change care before recommending testing. A laboratory result is not interpreted in isolation and does not establish a diagnosis by itself.
Before requesting this test
Availability, collection requirements, eligibility, and processing estimates can change. Sunridge reviews each request and, when appropriate, creates the order through Fullscript. Follow the current instructions supplied with the approved order.
About this test
Histamine is a bioactive molecule that functions as an important neurotransmitter and inflammatory mediator. Histamine intolerance occurs when there is an imbalance between histamine accumulation and the body’s ability to break it down. Histamine intolerance is mainly caused by low levels of an enzyme called DAO. This enzyme helps break down histamine in the digestive system. When there isn’t enough DAO, histamine builds up and causes symptoms. Some individuals inherit genetic variations that reduce their ability to produce adequate amounts of DAO enzyme or affect how efficiently the enzyme functions. Conditions such as SIBO (small intestinal bacterial overgrowth), IBS (irritable bowel syndrome), IBD (inflammatory bowel disease), celiac disease, and gut permeability (leaky gut) can damage intestinal cells that produce DAO enzymes, leading to excess histamine. Certain drugs including some antibiotics, anti-depressants, and pain relievers can block DAO activity or release histamine from cells. Consuming excessive amounts of histamine-rich foods can overwhelm even normal DAO levels, temporarily creating intolerance symptoms.
Additional details
This test analyzes genetic SNPs in the DAO (AOC1) gene that may affect the body's ability to break down histamine in the gut.
Highlighted health areas
- Genetics
Biomarkers and report focus
The exact analytes and report format can change. Confirm the current contents in the Fullscript order before payment.
- AOC1