Juvenile Polyposis Panel (BMPR1A and SMAD4)

Catalog information reviewed: August 24, 2026 by the Sunridge Medical clinical team.

What this laboratory test evaluates

DetailsJuvenile Polyposis Panel (BMPR1A and SMAD4) – This test looks for specific genetic changes in the BMPR1A and SMAD4 genes that are linked to Juvenile Polyposis syndrome (JPS). People with JPS have a higher chance of developing colorectal cancer (40-50%) and stomach cancer (up to 21%, especially if they have many polyps in their stomach). They also have a slightly increased risk for cancers of the small intestine and pancreas. Identifying these genetic mutations can help manage and reduce the risk of cancer.

Who should consider this test?This test is particularly important for individuals who have a family history of JPS or who have symptoms that could suggest JPS.

What type of sample is required for this test?5 mL whole blood collected in an EDTA (lavender-top) or ACD (yellow-top) tube. A simple blood draw is needed.

Test Resources https://education.questdiagnostics.com/faq/FAQ241

Additional test information

This test looks for specific genetic changes in the BMPR1A and SMAD4 genes that are linked to Juvenile Polyposis syndrome (JPS).

Collection and processing

• Sample type: Whole blood
• Fasting: No
• Estimated laboratory processing: Results should be available in 2 – 5 business days after the sample is collected

How Sunridge uses laboratory information

Sunridge considers the medical question, symptoms, history, medications, prior results, and whether the finding could change care before recommending testing. A laboratory result is not interpreted in isolation and does not establish a diagnosis by itself.

Before requesting this test

Availability, collection requirements, eligibility, and processing estimates can change. Sunridge reviews each request and, when appropriate, creates the order through Fullscript. Follow the current instructions supplied with the approved order.