Lp-PLA2 Activity

Catalog information reviewed: August 24, 2026 by the Sunridge Medical clinical team.

What this laboratory test evaluates

Lp-PLA2 Activity
This test measures the activity of Lipoprotein-associated phospholipase A2 (Lp-PLA2), an enzyme linked to inflammation and found in atherosclerotic plaques. High levels of Lp-PLA2 are associated with an increased risk of coronary heart disease and stroke. This test can help identify individuals at higher risk of cardiovascular events, aiding in the decision to start or intensify risk reduction strategies.

What patients is this test right for?This test is particularly useful for individuals who are being evaluated for cardiovascular disease risk, alongside traditional risk factors.

What type of sample is required for this test?1 mL serum.
A simple blood draw is needed.

Test ResourcesInformation currently not available.

Additional test information

Lipoprotein-associated phospholipase A2 (Lp-PLA2), also known as platelet activating factor Acetylhydrolase, is an inflammatory enzyme that circulates bound mainly to low density lipoproteins and has been found to be localized and enriched in atherosclerotic plaques. In multiple clinical trials, Lp-PLA2 activity has been shown to be an independent predictor of coronary heart disease and stroke in the general population. Measurement of Lp-PLA2 may be used along with traditional cardiovascular risk factor measures for identifying individuals at higher risk of cardiovascular disease events. Clinical management may include beginning or intensifying risk reduction strategies. The activity assay is an enzyme assay run on an automated chemistry platform.

Collection and processing

• Sample type: Serum
• Fasting: No
• Estimated laboratory processing: Results should be available in 2 – 5 business days after the sample is collected

How Sunridge uses laboratory information

Sunridge considers the medical question, symptoms, history, medications, prior results, and whether the finding could change care before recommending testing. A laboratory result is not interpreted in isolation and does not establish a diagnosis by itself.

Before requesting this test

Availability, collection requirements, eligibility, and processing estimates can change. Sunridge reviews each request and, when appropriate, creates the order through Fullscript. Follow the current instructions supplied with the approved order.