Mutated Citrullinated Vimentin (MCV) Antibody

Catalog information reviewed: August 24, 2026 by the Sunridge Medical clinical team.

What this laboratory test evaluates

DetailsMutated Citrullinated Vimentin (MCV) Antibody – This test is used to help diagnose rheumatoid arthritis (RA) by detecting specific antibodies. It's often used alongside other markers like rheumatoid factor and anti-cyclic citrullinated peptide (CCP). While MCV antibody is slightly less specific than CCP, it offers a bit higher sensitivity, improving RA diagnosis by 5-10% when combined with CCP. A positive MCV antibody test also indicates a more severe form of the disease and a greater likelihood of joint damage over time.

What patients is this test right for?This test is suitable for individuals showing symptoms of rheumatoid arthritis or those with a family history of RA. Symptoms include:

• Joint pain and swelling
• Stiffness, especially in the morning
• Chronic fatigue
• Weight loss
• Fever

What type of sample is required for this test?1 mL serum. A simple blood draw is needed.

Additional test information

This test is suitable for individuals showing symptoms of rheumatoid arthritis or those with a family history of RA.

Collection and processing

• Sample type: Serum
• Fasting: No
• Estimated laboratory processing: Results should be available in 2 – 5 business days after the sample is collected

How Sunridge uses laboratory information

Sunridge considers the medical question, symptoms, history, medications, prior results, and whether the finding could change care before recommending testing. A laboratory result is not interpreted in isolation and does not establish a diagnosis by itself.

Before requesting this test

Availability, collection requirements, eligibility, and processing estimates can change. Sunridge reviews each request and, when appropriate, creates the order through Fullscript. Follow the current instructions supplied with the approved order.