Compare this test’s laboratory options
PSA, Free and Total
Quest Diagnostics1 test optionFrom $18.90
PSA, Free and Total
Quest DiagnosticsCatalog information reviewed: August 24, 2026 by the Sunridge Medical clinical team.
What this laboratory test evaluates
DetailsPSA, Total with Reflex to PSA, Free – In men over 50 years with Total PSA between 4.0 and 10.0 ng/mL, the percent (%) Free PSA gives an estimate of the probability of cancer. In these circumstances the measurement of the % Free PSA may aid in avoiding unnecessary biopsies. Elevated levels of prostate specific antigen (PSA) have been associated with benign and malignant prostatic disorders. Studies indicate that in men 50 years or older measurement of PSA is a useful addition to the digital rectal exam in the early detection of prostate cancer. In addition, PSA decreases to undetectable levels following complete resection of the tumor and may rise again with recurrent disease or persist with residual disease. Thus, PSA levels may be of assistance in the management of prostate cancer patients.
What type of sample is required for this test?2 mL frozen serum
Test ResourcesFor more information, please consult your healthcare provider.
Additional test information
PSA, Total with Reflex to PSA, Free – In men over 50 years with Total PSA between 4.0 and 10.0 ng/mL, the percent (%) Free PSA gives an estimate of the probability of cancer. In these circumstances the measurement of the % Free PSA may aid in avoiding unnecessary biopsies. Elevated levels of prostate specific antigen (PSA) have been associated with benign and malignant prostatic disorders. Studies indicate that in men 50 years or older measurement of PSA is a useful addition to the digital rectal exam in the early detection of prostate cancer. In addition, PSA decreases to undetectable levels following complete resection of the tumor and may rise again with recurrent disease or persist with residual disease. Thus, PSA levels may be of assistance in the management of prostate cancer patients.
Collection and processing
- Sample type: Serum
- Fasting: No
- Estimated laboratory processing: Results should be available in 2 – 5 business days after the sample is collected
How Sunridge uses laboratory information
Sunridge considers the medical question, symptoms, history, medications, prior results, and whether the finding could change care before recommending testing. A laboratory result is not interpreted in isolation and does not establish a diagnosis by itself.
Before requesting this test
Availability, collection requirements, eligibility, and processing estimates can change. Sunridge reviews each request and, when appropriate, creates the order through Fullscript. Follow the current instructions supplied with the approved order.
Common questions about this laboratory test
- What sample does this test require?
- The listed sample type is Serum. Confirm current collection instructions in the approved order.
- Does this test require fasting?
- The current catalog record lists fasting as: No. Follow the instructions supplied with the approved order.
- How long does laboratory processing usually take?
- Results should be available in 2 – 5 business days after the sample is collected. Timing can change after collection or if a laboratory requires additional review.
About this test
DetailsPSA, Total with Reflex to PSA, Free - In men over 50 years with Total PSA between 4.0 and 10.0 ng/mL, the percent (%) Free PSA gives an estimate of the probability of cancer. In these circumstances the measurement of the % Free PSA may aid in avoiding unnecessary biopsies. Elevated levels of prostate specific antigen (PSA) have been associated with benign and malignant prostatic disorders. Studies indicate that in men 50 years or older measurement of PSA is a useful addition to the digital rectal exam in the early detection of prostate cancer. In addition, PSA decreases to undetectable levels following complete resection of the tumor and may rise again with recurrent disease or persist with residual disease. Thus, PSA levels may be of assistance in the management of prostate cancer patients.
What type of sample is required for this test?2 mL frozen serum
Test ResourcesFor more information, please consult your healthcare provider.
Additional details
PSA, Total with Reflex to PSA, Free - In men over 50 years with Total PSA between 4.0 and 10.0 ng/mL, the percent (%) Free PSA gives an estimate of the probability of cancer. In these circumstances the measurement of the % Free PSA may aid in avoiding unnecessary biopsies. Elevated levels of prostate specific antigen (PSA) have been associated with benign and malignant prostatic disorders. Studies indicate that in men 50 years or older measurement of PSA is a useful addition to the digital rectal exam in the early detection of prostate cancer. In addition, PSA decreases to undetectable levels following complete resection of the tumor and may rise again with recurrent disease or persist with residual disease. Thus, PSA levels may be of assistance in the management of prostate cancer patients.
Highlighted health areas
- Tumor markers
- Men's health
Biomarkers and report focus
The exact analytes and report format can change. Confirm the current contents in the Fullscript order before payment.
- Prostate-specific antigen (PSA), Total
- Prostate-specific antigen (PSA), % Free
- Prostate-specific antigen (PSA), Free