Zonulin Profile (Stool)

What this laboratory test evaluates

Diagnostic Solutions Laboratory's Zonulin Profile is a diagnostic test that measures the level of zonulin in the body. Zonulin is a protein that regulates the permeability of the tight junctions between cells in the digestive tract. It controls the flow of molecules, including nutrients and antigens, between the bloodstream and the intestinal lumen.

Zonulin has emerged as a popular serological marker to assess the integrity of the intestinal mucosal barrier. Elevated levels of zonulin have been associated with autoimmune diseases, such as celiac disease.

Additional test information

This test measures zonulin, a protein that modulates the permeability of tight junctions between cells of the wall of the digestive tract. It is used to help diagnose intestinal permeability/leaky gut and can be ordered as an add-on to the GI-MAP.

Collection and processing

• Sample type: Stool
• Fasting: No
• Estimated laboratory processing: Results should arrive 7 – 14 business days after the lab receives samples.

How Sunridge uses laboratory information

Sunridge considers the medical question, symptoms, history, medications, prior results, and whether the finding could change care before recommending testing. A laboratory result is not interpreted in isolation and does not establish a diagnosis by itself.

Before requesting this test

Availability, collection requirements, eligibility, and processing estimates can change. Sunridge reviews each request and, when appropriate, creates the order through Fullscript. Follow the current instructions supplied with the approved order.

Related Sunridge care

Learn how Sunridge approaches Digestive Conditions and ask whether this test is appropriate for your clinical question.