Anti-cancer effects of Bifidobacterium species in colon cancer cells and a mouse model of carcinogenesis.
Selected Bifidobacterium combinations promoted apoptosis and reduced EGFR, HER2 and COX-2 expression in colorectal-cancer research.
MICROBIOME · DIGESTIVE RESILIENCE · IMMUNE SIGNALING
Probiotics, the Microbiome and Cancer Research
Cancer and its treatment can reshape the intestinal microbiome. Research is examining selected probiotics for digestive symptoms, surgical recovery, quality of life and immune-treatment interactions.
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PHYSICIAN-DIRECTED INTEGRATIVE CARE
Research organized around the cancer and the person
Sunridge approaches probiotics by strain, dose, treatment phase and patient context. The question is not simply whether a product says “probiotic,” but which organisms and goals fit the person’s care plan.
Bowel symptoms and quality of life
Chemotherapy and radiation tolerance
Surgical recovery and barrier function
Microbiome and immune response
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Studies grouped by cancer type
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Lactobacillus supplementation for diarrhoea related to chemotherapy of colorectal cancer: a randomised study.
Lactobacillus rhamnosus GG was associated with less severe diarrhea, fewer hospital visits and fewer chemotherapy dose reductions during 5-FU treatment.
Immune Responses Raised in an Experimental Colon Carcinoma Model Following Oral Administration of Lactobacillus casei.
Lactobacillus casei increased tumor interferon-gamma, granzyme B and CD8 T-cell infiltration alongside suppressed growth and increased apoptosis markers.
Effects of 12 weeks of probiotic supplementation on quality of life in colorectal cancer survivors: a double-blind, randomized, placebo-controlled trial.
A randomized placebo-controlled trial in colorectal-cancer survivors reported improved bowel symptoms, functional well-being, fatigue and cancer-related quality of life after 12 weeks.
Randomised clinical trial: the effects of perioperative probiotic treatment on barrier function and post-operative infectious complications in colorectal cancer surgery - a double-blind study.
A double-blind randomized study reported improved intestinal-barrier measures, peristalsis recovery and infectious-complication outcomes after colorectal surgery.
The effect of perioperative probiotics treatment for colorectal cancer: short-term outcomes of a randomized controlled trial.
A randomized colorectal-resection trial reported earlier bowel recovery and less postoperative diarrhea in the probiotic group.
Effect of probiotics combined with immune checkpoint suppressors and chemotherapeutic agents on digestive system function, intestinal immunity and prognosis in patients with metastatic colorectal carcinoma: a quasi-experimental study.
A study combining probiotics with systemic treatment reported improved intestinal and immune measures and quality-of-life outcomes in metastatic colorectal cancer.
Preventive and Tumor-Suppressive Effects of Lactobacillus Paracasei X12 in Rat Model of Colorectal Cancer.
Lactobacillus paracasei X12 reduced neoplasia incidence, proliferation and tumor growth and favorably shifted apoptosis markers in the reported model.
Lactobacillus rhamnosus induced epithelial cell apoptosis, ameliorates inflammation and prevents colon cancer development in an animal model.
Lactobacillus rhamnosus GG reduced colon-tumor incidence, multiplicity and volume while lowering inflammatory signaling.
Dietary intervention reshapes gut microbiota and lipid metabolism to enhance anti-tumor immunity and prognosis in hepatocellular carcinoma: a randomized controlled trial.
A randomized microbiome-directed dietary intervention including probiotics reported improved progression-free survival, overall survival and quality of life in hepatocellular carcinoma.
Oral compound probiotic supplements can improve the quality of life for patients with lung cancer during chemotherapy: A randomized placebo-controlled study.
A randomized placebo-controlled study found better overall quality of life and fewer gastrointestinal symptoms during platinum-based chemotherapy.
Modulating the gut microbiome to enhance cancer immunotherapy: a systematic review and Meta-Analysis of probiotics and FMT as adjuncts.
A systematic review and meta-analysis found microbiome interventions were associated with improved progression-free and overall-survival measures during checkpoint-inhibitor treatment.
Impact of probiotic supplementation on chemotherapy and radiotherapy-associated diarrhea and quality of life.
Clinical research has evaluated Lactobacillus supplementation for chemotherapy- and radiotherapy-associated diarrhea and patient-reported quality of life.
Randomized trial assessing impact of probiotic supplementation on gut microbiome and clinical outcome from targeted therapy in metastatic renal cell carcinoma.
A randomized study showed that a Bifidobacterium-containing probiotic could successfully change measurable gut-microbiome composition during targeted therapy.
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