Resveratrol cancer treatment is a polyphenol compound found naturally in plants and in certain foods such as red wines, grapes, and peanuts. Resveratrol is a very important phytonutrient and a part of treatment for cancer care. Resveratrol is able to introduce apoptosis in cancer cells while protecting healthy cells.
Resveratrol Cancer Treatment exhibits antiestrogenic activity which inhibits the growth of breast cancer cells. It has also been shown to suppress the proliferation of a wide variety of tumor cells, including lymphoid and myeloid cancers; breast cancer, colon cancer, pancreatic cancer, gastric cancer, prostate cancer, ovarian cancer, liver cancer, lung cancer, and skin cancer along with cervical cancer.
Resveratrol: Wine and Grapes
Resveratrol is believed to be the answer to the “French Paradox” because people in southern France who drink red wine have a lower incidence of coronary heart disease despite a high intake of saturated fats. It also provides protection for the nervous system.
The mechanism of action of resveratrol cancer treatment includes the stimulation of multiple cell signaling pathways, such as Sirt1 (a sirtuin enzyme) which is a key regulator of gene activity related to cell defenses and survival in response to stress.
Evidence-Based Resveratrol Benefits
Learning about our patients as individuals and their cancer type is critically important in determining the benefits of resveratrol cancer treatment and how it will work best to fight cancer. Treating cancer and working with patients to regain health is what Sunridge Medical does best.
Conventional cancer approaches of chemotherapy and radiation cannot be continually utilized because of their high toxicity and terrible side effects which often are more dangerous to a long life than cancer itself.
Sunridge Medical offers cancer solutions based on the newest, evidence-based holistic, alternative, and integrative treatments based on the patient’s body chemistry and medical history.
References on Resveratrol Cancer Treatment
Carter LG, D’Orazio JA, Pearson KJ. Resveratrol and cancer: focus on in vivo evidence. Endocr Relat Cancer. 2014 May 6;21(3):R209-25. doi: 10.1530/ERC-13-0171. PMID: 24500760; PMCID: PMC4013237. https://pubmed.ncbi.nlm.nih.gov/24500760 Resveratrol is a naturally occurring polyphenol that provides a number of anti-aging health benefits including improved metabolism, cardio protection, and cancer prevention. Much of the work on resveratrol and cancer comes from in vitro studies looking at resveratrol actions on cancer cells and pathways. There are, however, comparatively fewer studies that have investigated resveratrol treatment and cancer outcomes in vivo, perhaps limited by its poor bioavailability when taken orally. Although research in cell culture has shown promising and positive effects of resveratrol, evidence from rodents and humans is inconsistent.
This review highlights the in vivo effects of resveratrol treatment on breast, colorectal, liver, pancreatic, and prostate cancers. Resveratrol supplementation in animal models of cancer has shown positive, neutral as well as negative outcomes depending on resveratrol route of administration, dose, tumor model, species, and other factors. Within a specific cancer type, there is variability between studies with respect to strain, age, and sex of animal used, timing and method of resveratrol supplementation, and dose of resveratrol used to study cancer endpoints. Together, the data suggest that many factors need to be considered before resveratrol can be used for human cancer prevention or therapy. Peter A. Baghurst, Anthony J. McMichael, Anthony H. Slavotinek, Katrine I. Baghurst, Peter Boyle, Alexander M. Walker, A Case-Control Study of Diet and Cancer of the Pancreas, American Journal of Epidemiology, Volume 134, Issue 2, 15 July 1991, Pages 167–179, https://doi.org/10.1093/oxfordjournals.aje.a116069 In a population-based case-control study carried out in Adelaide, South Australia, during the years 1984–1987, the diets of 104 cases of cancer of the pancreas 1 year prior to diagnosis were compared with the diets of 253 community controls. A quantitative food-frequency questionnaire was used to assess usual dietary intakes of 179 food items.
Cases were compared with controls in terms of both the amounts of individual food items consumed and the estimated contributions of 48 nutrients to the diet. Food items consumed more by cases than controls included boiled eggs and omelets as well as a number of items that could be collectively described as sweet and fatty. Food items consumed less by cases than controls included several vegetables and fruits. Conditional logistic regression analysis of nutrient intake adjusted for total energy and for alcohol and tobacco usage yielded an estimate of relative risk of 3.19, with a 95% confidence interval of 1.58–6.47 for the highest quartile of cholesterol intake (relative to the lowest quartile).
For the top quartile of refined sugar intake, the estimated relative risk was 2.21 (95% confidence interval 1.07–4.55). Several nutrients derived principally from plant foods were statistically significantly associated with lower risks. Alcohol consumption was significantly lower among cases than controls. Current smokers had a relative risk of 1.76 (95% confidence interval 0.93–3.34) relative to those who had never smoked. There was no association of pancreatic cancer with coffee drinking. Am J Epidemiol 1991; 134: 167–79.
Resveratrol and Various Cancer Types
Almatroodi SA, A Alsahli M, S M Aljohani A, Alhumaydhi FA, Babiker AY, Khan AA, Rahmani AH. Potential Therapeutic Targets of Resveratrol, a Plant Polyphenol, and Its Role in the Therapy of Various Types of Cancer. Molecules. 2022 Apr 21;27(9):2665. doi: 10.3390/molecules27092665. PMID: 35566016; PMCID: PMC9101422. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101422/Cancer is among the most prominent causes of mortality worldwide. Different cancer therapy modes employed, including chemotherapy and radiotherapy, have been reported to be significant in cancer management, but the side effects associated with these treatment strategies are still a health problem. Therefore, alternative anticancer drugs based on medicinal plants or their active compounds have been generating attention because of their less serious side effects. Medicinal plants are an excellent source of phytochemicals that have been recognized to have health-prompting effects through modulating cell signaling pathways. Resveratrol is a well-known polyphenolic molecule with antioxidant, anti-inflammatory, and health-prompting effects among which its anticancer role has been best defined.Additionally, this polyphenol has confirmed its role in cancer management because it activates tumor suppressor genes, suppresses cell proliferation, induces apoptosis, inhibits angiogenesis, and modulates several other cell signaling molecules.
The anticancer potential of resveratrol is recognized in numerous in vivo and in vitro studies. Previous experimental data suggested that resveratrol may be valuable in cancer management or improve the efficacy of drugs when given with anticancer drugs. This review emphasizes the potential role of resveratrol as an anticancer drug by modulating numerous cell signaling pathways in different types of cancer.
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